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Actos
Pioglitazone
$144.00
15mg · 3 × 28 tablets · 3 months supply
BrandBranded medicine· By Abic
$48.00 per month
Strength
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Annual cost
$624a year at this pack size
Prescription required
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FDA boxed warningCongestive heart failure
Thiazolidinediones, including ACTOS ®, cause or exacerbate congestive heart failure in some patients.
After initiation of ACTOS, and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated.
About Actos
Overview
Actos contains pioglitazone, an oral diabetes medicine supplied as tablets. It is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes. It works by helping the body respond better to its own insulin and reducing the amount of sugar released by the liver. It is not for treating type 1 diabetes or diabetic ketoacidosis.
What it treats
To improve blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Safety information
Side effects
Common side effects of Actos (pioglitazone) include upper respiratory tract infections, headache, sinus infections, muscle pain and sore throat. Contact your doctor if you develop swelling or changes in vision. Actos can cause fluid retention, which may cause or worsen congestive heart failure. This risk may be higher when Actos is used with insulin or in people who already have heart failure. Swelling at the back of the eye (macular edema) has also been reported; sudden vision changes need prompt assessment. Other serious risks include low blood sugar when used with insulin or medicines that increase insulin release, liver failure that has sometimes been fatal, and an increased risk of fractures in women. Actos may also increase the risk of bladder cancer. It must not be used in people with active bladder cancer, and caution is needed in those with a history of bladder cancer. Discuss these risks with your doctor.
FDA boxed warning
Congestive heart failure
Thiazolidinediones, including ACTOS ®, cause or exacerbate congestive heart failure in some patients.
After initiation of ACTOS, and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Actos if you are allergic to pioglitazone or any other ingredient. Actos must not be started in people with established severe heart failure (NYHA Class III or IV) and must not be used in people with active bladder cancer. It is not recommended for children. Actos can cause fluid retention and swelling, which may cause or worsen heart failure. Extra caution and monitoring are needed in people with milder heart failure (NYHA Class I or II) or those using insulin. Using Actos with insulin or medicines that stimulate insulin release can also increase the risk of low blood sugar. Tell your prescriber if you have previously had bladder cancer. Liver failure, sometimes fatal, has been reported. If liver injury is detected, treatment should be interrupted promptly and the cause assessed. Actos should not be restarted if liver injury is confirmed and no other cause is found. Other precautions include an increased risk of fractures in women and reports of macular edema, a type of swelling in the eye. Regular eye examinations are recommended, and sudden vision changes need prompt assessment. Premenopausal women should be aware of the potential for unintended pregnancy.
Interactions
Tell your doctor if you take gemfibrozil, rifampin or topiramate. Gemfibrozil can increase the amount of pioglitazone in your blood, so your prescriber may need to limit your Actos dose. Rifampin and topiramate may decrease the amount of pioglitazone in your blood.
Using Actos
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label ACTOS (PIOGLITAZONE) TABLET [TAKEDA PHARMACEUTICALS AMERICA, INC.] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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