Auvelity

Before taking this medicine

Do not take Auvelity if you: • Have a seizure disorder. • Have or have previously had bulimia or anorexia nervosa. • Are abruptly stopping alcohol, benzodiazepines, barbiturates or antiepileptic medicines. • Take a monoamine oxidase inhibitor (MAOI), including linezolid or intravenous methylene blue, or have stopped an MAOI within the past 14 days. Do not start an MAOI within 14 days of stopping Auvelity. These combinations can cause serious, potentially fatal reactions. • Are allergic to dextromethorphan, bupropion or any other ingredient in Auvelity. Auvelity should be avoided in people with severe liver impairment. It may harm an unborn baby; the label advises stopping treatment during pregnancy and using an alternative treatment when planning pregnancy. Contact your prescriber if you are pregnant or planning pregnancy. Breastfeeding is not recommended during treatment. Auvelity can cause seizures, raise blood pressure and trigger mania or hypomania. Blood pressure should be checked before treatment and periodically during treatment, and patients should be screened for bipolar disorder. Untreated narrow drainage angles in the eyes increase the risk of angle-closure glaucoma. Low blood sodium can also occur. Taking Auvelity with an SSRI or tricyclic antidepressant increases the risk of serotonin syndrome. Treatment must be stopped if serotonin syndrome or a seizure occurs. Contact a healthcare professional if psychosis or other unusual mental or behavioural changes occur. Auvelity may cause dizziness; take precautions to prevent falls and use caution when operating machinery.