Complera

Before taking this medicine

Do not take Complera with carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin, rifapentine, systemic dexamethasone given more than once, St John’s wort, or proton pump inhibitors such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole or rabeprazole. These combinations can reduce its effectiveness and may lead to drug resistance. Conditions requiring caution include liver disease, raised liver test results, kidney problems, severe depression, and a history of fractures caused by weakened bones or other risk factors for osteoporosis or bone loss. Liver tests and, where appropriate, bone density monitoring may be needed. Avoid use with medicines that can damage the kidneys, including those used recently. Medicines known to prolong the heart’s QTc interval may increase the risk of a serious abnormal heart rhythm called Torsade de Pointes. Severe skin and allergic reactions, including DRESS, have been reported. Stop treatment and seek immediate medical care if a severe allergic reaction occurs, or if a rash develops with symptoms affecting the rest of the body or raised liver tests. Severe depression requires immediate medical assessment. Treatment must also be stopped if symptoms or test results suggest lactic acid buildup or serious liver toxicity. Immune system changes during treatment may require further assessment and treatment. During pregnancy, close viral load monitoring is needed because rilpivirine exposure may be lower. Breastfeeding is not recommended because of the potential for HIV-1 transmission. Complera is not recommended for patients weighing less than 35 kg.