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Desyrel
Trazodone
$99.00
50mg · 3 × 84 capsules · 3 months supply
GenericGeneric medicine
$33.00 per month
Strength
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Annual cost
$429a year at this pack size
Prescription required
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50mg
100mg
FDA boxed warningSuicidal thoughts and behaviors
Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors
. Trazodone is not approved for use in pediatric patients
Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors
About Desyrel
Overview
Desyrel contains trazodone, an antidepressant. It is used to treat major depressive disorder (MDD). It is thought to work by increasing serotonin activity in the brain, although its antidepressant action is not fully understood.
What it treats
Major depressive disorder (MDD).
Safety information
Side effects
Common side effects include swelling, blurred vision, fainting, drowsiness, tiredness, diarrhea, a blocked nose and weight loss. Trazodone can also cause a drop in blood pressure when standing. It may impair judgment, thinking and coordination. Avoid driving or operating hazardous machinery until you know how it affects you. Serious side effects need prompt medical attention: - New or worsening suicidal thoughts or behavior, worsening depression, or unusual behavior changes. Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents and young adults. Monitoring is especially important during the first few months of treatment and when treatment changes. - Serotonin syndrome, a potentially life-threatening reaction. Symptoms may include agitation, hallucinations, fever, sweating, a rapid heartbeat, changing blood pressure, muscle stiffness or twitching, tremor, seizures, vomiting or diarrhea. It can occur with trazodone alone, but the risk is higher with other medicines that affect serotonin. Seek emergency medical care if these symptoms occur. - Abnormal heart rhythms, which can be life-threatening. Trazodone can prolong the QT interval, a change in the heart’s electrical activity. A rapid heartbeat with fainting needs urgent medical assessment. - Unusual bruising or bleeding, which can be severe or life-threatening. The risk is higher with aspirin, NSAIDs, antiplatelet medicines or anticoagulants such as warfarin. - An erection lasting more than four hours, whether painful or not. Stop taking trazodone and seek emergency medical attention immediately because permanent damage can occur. - Mania or hypomania. Tell your doctor about any personal or family history of bipolar disorder, mania or hypomania. - Angle-closure glaucoma, an eye condition that trazodone may trigger in people with untreated narrow drainage angles in the eyes. - Low blood sodium, which can cause headache, difficulty concentrating, memory problems, confusion, weakness or unsteadiness. Severe cases can cause hallucinations, fainting, seizures, coma or death. Older adults, people taking diuretics and people with reduced body fluid levels may be at greater risk. Stopping trazodone suddenly can cause withdrawal symptoms, including nausea, sweating, irritability, anxiety, dizziness, electric shock-like sensations, sleep problems and seizures. Speak with your prescriber before stopping treatment.
FDA boxed warning
Suicidal thoughts and behaviors
Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors
. Trazodone is not approved for use in pediatric patients
Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take trazodone with a monoamine oxidase inhibitor (MAOI), or within 14 days of stopping an MAOI. This includes linezolid and intravenous methylene blue. Trazodone should be avoided if you have a history of abnormal heart rhythms, a prolonged QT interval, or conditions that increase the risk of dangerous heart rhythms, such as a symptomatic slow heartbeat or low potassium or magnesium levels. It should also be avoided with medicines that prolong the QT interval or inhibit the enzyme CYP3A4, such as clarithromycin or itraconazole. It is not recommended during early recovery from a heart attack. People with heart disease need close monitoring. Avoid trazodone if you have untreated narrow drainage angles in the eyes, as it may trigger angle-closure glaucoma. Tell your prescriber if you have: • Low blood pressure or fainting, or take blood pressure medicines. • A personal or family history of bipolar disorder, mania or hypomania. Trazodone may trigger a manic episode. • Sickle cell anaemia, multiple myeloma, leukaemia or an abnormal shape of the penis, which may increase the risk of prolonged erections. • Low sodium levels, take diuretics, or have reduced fluid levels. Older people are also at greater risk of low sodium. Other medicines that affect serotonin, including some antidepressants, migraine medicines, tramadol, lithium and St John’s wort, increase the risk of potentially life-threatening serotonin syndrome. This can also occur with trazodone alone. Aspirin, NSAIDs, antiplatelet medicines and anticoagulants increase bleeding risk; people taking warfarin need careful blood-clotting monitoring. Monitor for worsening depression, unusual behaviour or suicidal thoughts, especially early in treatment or when treatment changes. Antidepressants increase the risk of suicidal thoughts and behaviour in children and young adults. Trazodone may cause sleepiness and impair judgement or coordination. Avoid driving or hazardous machinery until you know how it affects you. Stopping suddenly can cause withdrawal symptoms; discuss stopping with your prescriber. If an erection lasts longer than four hours, whether painful or not, stop trazodone and seek emergency medical attention.
Interactions
Trazodone has important interactions with medicines, supplements and alcohol: • Do not take trazodone with monoamine oxidase inhibitors (MAOIs), including linezolid or intravenous methylene blue, because of the increased risk of serotonin syndrome. • Other medicines and supplements that affect serotonin also increase this risk. These include other antidepressants, triptans, fentanyl, lithium, tramadol, tryptophan, buspirone and St. John’s wort. Your doctor should monitor for serotonin syndrome, especially when trazodone is started. • Blood thinners and antiplatelet medicines, such as warfarin, rivaroxaban, dabigatran and clopidogrel, can increase bleeding risk. People taking warfarin need careful INR monitoring when starting or stopping trazodone. • Itraconazole, ketoconazole, clarithromycin and indinavir can increase trazodone exposure and the risk of side effects, including abnormal heart rhythms. Rifampin, carbamazepine, phenytoin and St. John’s wort can reduce trazodone exposure. Your prescriber may need to review your treatment. • Trazodone can increase blood levels of digoxin and phenytoin. Blood-level monitoring is needed before and during combined treatment. • Trazodone may increase the effects of alcohol, barbiturates and other medicines that depress the central nervous system. • Avoid combining trazodone with medicines known to prolong the QT interval, a change in the heart’s electrical activity that can increase the risk of abnormal heart rhythms. Examples include quinidine, procainamide, disopyramide, amiodarone, sotalol, ziprasidone, chlorpromazine, thioridazine and gatifloxacin.
Using Desyrel
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label TRAZODONE HYDROCHLORIDE TABLET [PD-RX PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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