Januvia

Before taking this medicine

Do not take Januvia if you have previously had a serious allergic reaction to sitagliptin, including anaphylaxis or angioedema (swelling beneath the skin). Januvia requires caution in people with risk factors for heart failure or kidney problems. Heart failure has been observed with two other medicines in the same drug class. Kidney function should be checked before treatment and periodically during treatment; acute kidney failure, sometimes requiring dialysis, has been reported. Taking Januvia with insulin or medicines that stimulate insulin release increases the risk of low blood sugar. Serious inflammation of the pancreas (pancreatitis), including fatal cases, has been reported. Januvia should be stopped promptly if pancreatitis is suspected. Serious allergic reactions, including severe skin reactions such as Stevens-Johnson syndrome, also require prompt stopping and medical assessment. Severe, disabling joint pain and a blistering skin condition called bullous pemphigoid have been reported with medicines in this class. Report severe joint pain, blisters or open skin sores to your prescriber. Januvia should be stopped if bullous pemphigoid is suspected; your prescriber may also stop treatment if severe joint pain occurs.