Latuda

Before taking this medicine

Do not take Latuda if you are allergic to lurasidone hydrochloride or any of its ingredients. Angioedema (swelling beneath the skin) has been reported. Do not take Latuda with strong CYP3A4 inhibitors, such as ketoconazole, clarithromycin, ritonavir or voriconazole, or strong CYP3A4 inducers, such as rifampin, St. John’s wort, phenytoin or carbamazepine. Conditions requiring caution include: • Dementia-related psychosis in older adults, because of an increased risk of stroke or transient ischaemic attack. • Diabetes or high blood sugar, abnormal blood fats or weight gain. These should be monitored during treatment. • A low white blood cell count or a history of low white blood cells, which requires blood count monitoring. • Heart or blood vessel disease, a history of stroke, or a risk of dehydration or fainting. Heart rate and blood pressure should be monitored because Latuda can cause a drop in blood pressure on standing and fainting. • Pregnancy. Exposure during the third trimester may cause movement-related or withdrawal symptoms in newborns. Latuda can also cause elevated prolactin levels, tardive dyskinesia (involuntary movements) and neuroleptic malignant syndrome. Neuroleptic malignant syndrome requires immediate discontinuation and close monitoring; tardive dyskinesia may require discontinuation if clinically appropriate.