Nexplanon, illustration of medicine carton form (not a photo of the actual pack)

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Nexplanon

Etonogestrel

Prescription required

$330.00

68mg · 1 box

BrandBranded medicine

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FDA boxed warningRisk of complications due to improper insertion and removal

Improper insertion of NEXPLANON increases the risk of complications.

Proper training prior to first use of NEXPLANON can minimize the risk of improper NEXPLANON insertion.

Because of the risk of complications due to improper insertion and removal NEXPLANON is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the NEXPLANON REMS.

Read this with the rest of the clinical information

About Nexplanon

Overview

Nexplanon is a soft, flexible contraceptive implant containing etonogestrel, a progestin hormone, and no estrogen. It is used to prevent pregnancy in women who can become pregnant. It works by stopping the release of an egg, thickening cervical mucus and changing the lining of the uterus.

What it treats

Prevention of pregnancy in women of reproductive potential for up to 5 years.

Safety information

Side effects

Common side effects include changes in menstrual bleeding, headache, vaginal inflammation, weight gain, acne, breast pain, abdominal pain and sore throat. Bleeding may become more or less frequent, heavier or lighter, or last longer or shorter than usual. Insertion or removal can cause pain, tingling or numbness, bleeding, bruising, scarring or infection. The implant may move into blood vessels, including those in the lungs, and surgery may be needed to remove it. Seek urgent medical attention for chest pain, shortness of breath, cough or coughing up blood. Contact a doctor promptly if you become pregnant or develop lower abdominal pain, as these may indicate a pregnancy outside the womb. Other serious concerns include blood clots, liver disease and a significant rise in blood pressure. The implant should be removed by a healthcare professional if a blood clot occurs, if you develop jaundice (yellowing of the skin or eyes), or if blood pressure rises significantly and cannot be controlled. People with prediabetes or diabetes need monitoring during use.

FDA boxed warning

Risk of complications due to improper insertion and removal

Improper insertion of NEXPLANON increases the risk of complications.

Proper training prior to first use of NEXPLANON can minimize the risk of improper NEXPLANON insertion.

Because of the risk of complications due to improper insertion and removal NEXPLANON is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the NEXPLANON REMS.

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

• Seek immediate medical attention for chest pain, trouble breathing, cough or coughing up blood. • Contact a doctor immediately if you become pregnant or have lower abdominal pain while using Nexplanon, because these may signal a pregnancy outside the womb. • Contact a doctor immediately if your skin or the whites of your eyes turn yellow.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Nexplanon must not be used if you have known or suspected pregnancy; current or previous blood clots or clot-related disorders; liver tumors or active liver disease; unexplained abnormal uterine bleeding; known or suspected breast cancer, a history of breast cancer, or another current or previous cancer sensitive to progestins; or an allergy to any component of Nexplanon. Insertion and removal can cause pain, tingling or numbness, bleeding, bruising, scarring or infection. The implant may move into blood vessels, including those in the lungs, and surgical removal may be needed. Symptoms can include chest pain, shortness of breath, cough or coughing up blood. Menstrual bleeding may change in frequency, amount or duration. Pregnancy or lower abdominal pain during use requires assessment for a possible ectopic pregnancy. The implant should be removed if a blood clot develops, jaundice occurs, or blood pressure rises significantly and becomes uncontrolled. People with prediabetes or diabetes need monitoring during use. If pregnancy occurs and is to be continued, Nexplanon should be discontinued.

Interactions

Some medicines and herbal products that increase the activity of certain enzymes, such as CYP3A4, may make Nexplanon less effective or increase breakthrough bleeding. Tell your doctor about any medicines or herbal products you use so they can check for interactions with Nexplanon.

Using Nexplanon

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in the original pack, away from direct light, heat and moisture. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label NEXPLANON (ETONOGESTREL) IMPLANT [ORGANON LLC] (DailyMed, retrieved 19 September 2026).

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