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Provocholine
Methacholine Chloride
$721.00
1
BrandBranded medicine· By Methapharm
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FDA boxed warningSevere bronchoconstriction
Severe bronchoconstriction can result from Provocholine administration (including the lowest dose). The use of Provocholine is contraindicated in pediatric and adult patients with baseline FEV1 < 60% predicted or adults with FEV1 < 1.5 L. Because of the potential for severe bronchoconstriction, the use of Provocholine in patients with clinically apparent asthma or wheezing is not recommended.
Emergency equipment and medication should be immediately available to treat acute respiratory distress. If severe bronchoconstriction occurs, reverse immediately with a rapid-acting inhaled bronchodilator agent (β-agonist).
If baseline spirometry is not performed or is measured inaccurately, the initial FEV1 may be underestimated. In this situation, decreases in FEV1 may not be detected after administration of escalating Provocholine doses, which may result in administration of unnecessary higher doses and an increased risk for excessive bronchoconstriction.
with FEV1 < 1.5 L
Use of Provocholine is not recommended in patients with clinically apparent asthma or wheezing
About Provocholine
Overview
Provocholine contains methacholine chloride and is used in a methacholine challenge test to help diagnose unusually sensitive airways. It is used in adults and children aged five years and older who do not have clinically apparent asthma. It works by stimulating receptors in the airway muscles, causing the airways to narrow.
What it treats
Used in a methacholine challenge test to diagnose overly reactive airways (bronchial airway hyperreactivity) in adults and children aged 5 years and older who do not have clinically apparent asthma.
Safety information
Side effects
Reported side effects include narrowing of the airways (bronchospasm), which may cause chest tightness, cough or wheezing. Less common side effects include headache, throat irritation, light-headedness and itching. The frequency of some reported reactions cannot be reliably estimated. Provocholine can cause severe narrowing of the airways that requires immediate treatment. Tell the healthcare professional administering the test immediately if you develop chest tightness, cough or wheezing.
FDA boxed warning
Severe bronchoconstriction
Severe bronchoconstriction can result from Provocholine administration (including the lowest dose). The use of Provocholine is contraindicated in pediatric and adult patients with baseline FEV1 < 60% predicted or adults with FEV1 < 1.5 L. Because of the potential for severe bronchoconstriction, the use of Provocholine in patients with clinically apparent asthma or wheezing is not recommended.
Emergency equipment and medication should be immediately available to treat acute respiratory distress. If severe bronchoconstriction occurs, reverse immediately with a rapid-acting inhaled bronchodilator agent (β-agonist).
If baseline spirometry is not performed or is measured inaccurately, the initial FEV1 may be underestimated. In this situation, decreases in FEV1 may not be detected after administration of escalating Provocholine doses, which may result in administration of unnecessary higher doses and an increased risk for excessive bronchoconstriction.
with FEV1 < 1.5 L
Use of Provocholine is not recommended in patients with clinically apparent asthma or wheezing
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Provocholine must not be used in people who are allergic to methacholine or other parasympathomimetic medicines. Reported allergic reactions include rash, itching, swelling of the face, tongue or throat, severe dizziness and difficulty breathing. It must not be used if baseline FEV1, a measure of lung function, is below 60% of the predicted value in adults or children, or below 1.5 litres in adults. Provocholine can cause severe narrowing of the airways. It is not recommended for people with clinically apparent asthma or wheezing, uncontrolled high blood pressure, an aortic aneurysm, or a history of heart attack or stroke. It is also not recommended during pregnancy. The clinician should weigh the benefits and risks in people with other conditions that could be worsened by a cholinergic medicine. Healthcare staff and others involved in the test should avoid accidental inhalation, which can also cause airway narrowing.
Interactions
Tell your doctor if you take beta-blockers, as they may make it harder to reverse airway narrowing caused by Provocholine. Beta-agonists (such as albuterol or salmeterol), anticholinergics (such as ipratropium or tiotropium), and theophylline can reduce the airways’ response to Provocholine. These medicines need to be withheld before the test; ask your doctor when to stop them. Regular use of oral or inhaled corticosteroids or inhaled cromoglycate may also reduce the response to Provocholine, but the label allows these medicines to be continued.
Using Provocholine
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label PROVOCHOLINE (METHACHOLINE CHLORIDE) POWDER, FOR SOLUTION PROVOCHOLINE INHALATION SOLUTION (METHACHOLINE CHLORIDE INHALATION SOLUTION) SOLUTION PROVOCHOLINE INHALATION SOLUTION (METHACHOLINE CHLORIDE INHALATION SOLUTION) KIT [METHAPHARM INC.] (DailyMed, retrieved 19 September 2026).
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