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Relistor
Methylnaltrexone Bromide
$1916.00
12mg · 4 × 7 syringes · 1 month supply
BrandBranded medicine· By Bausch & Lomb
$1916.00 per month
Annual cost
$24908a year at this pack size
Prescription required
Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.
About Relistor
Overview
Relistor contains methylnaltrexone bromide and is supplied in a pre-filled syringe for injection under the skin. It treats opioid-induced constipation in adults with chronic non-cancer pain, including pain related to past cancer or its treatment when frequent opioid dose increases are not needed. It also treats opioid-induced constipation in adults with advanced illness or active cancer pain who need increasing opioid doses for palliative care. It works by blocking the constipating effects of opioids in the gut without affecting their pain-relieving action in the brain and spinal cord.
What it treats
- Opioid-induced constipation in adults with chronic non-cancer pain, including pain related to previous cancer or its treatment, who do not need frequent increases in opioid dosage. - Opioid-induced constipation in adults with advanced illness or pain caused by active cancer who need increases in opioid dosage for palliative care.
Safety information
Side effects
Common side effects of Relistor injection include abdominal pain, nausea, diarrhea, increased sweating, hot flushes, trembling and chills in adults with opioid-induced constipation and chronic non-cancer pain. In adults with advanced illness, common side effects include abdominal pain, gas, nausea, dizziness and diarrhea. Serious side effects include a tear in the stomach or intestinal wall, severe or persistent diarrhea, and opioid withdrawal. Stop using Relistor and contact your doctor if you develop severe, persistent or worsening abdominal pain, or severe or persistent diarrhea. Contact your doctor if you experience symptoms of opioid withdrawal.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not use Relistor if you have a known or suspected blockage in your stomach or intestines, or are at increased risk of a blockage happening again, because of the risk of a tear in the stomach or intestinal wall. Your prescriber should carefully weigh the risks and benefits if you have conditions that may weaken the stomach or intestinal wall, such as peptic ulcers, Ogilvie’s syndrome, diverticular disease, Crohn’s disease, cancer involving the digestive tract wall, or cancer that has spread to the abdominal lining. Stop using Relistor if you develop severe, persistent or worsening abdominal pain. If severe or persistent diarrhea occurs, stop using it and consult your healthcare provider. Conditions that disrupt the blood-brain barrier require careful assessment and close monitoring for opioid withdrawal. Moderate or severe kidney impairment requires a prescriber-directed dose reduction. Severe liver impairment has not been studied with Relistor injection and requires monitoring for side effects. Relistor may cause opioid withdrawal in a fetus during pregnancy. Breastfeeding is not recommended during treatment.
Interactions
Avoid using Relistor with other opioid antagonists (medicines that block opioid effects), as their combined effects may increase the risk of opioid withdrawal. Tell your doctor if you take any of these medicines.
Using Relistor
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label RELISTOR (METHYLNALTREXONE BROMIDE) TABLET RELISTOR (METHYLNALTREXONE BROMIDE) INJECTION, SOLUTION [SALIX PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
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