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Losec OTC
Omeprazole OTC
$102.00
20mg · 3 × 28 capsules · 3 months supply
GenericGeneric medicine· By Abic
$34.00 per month
How long a supply?
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Annual cost
$442a year at this pack size
20mg
About Losec OTC
Overview
Losec OTC contains omeprazole, a proton pump inhibitor (PPI), in delayed-release capsules. Omeprazole is used in adults to treat active duodenal ulcers, noncancerous stomach ulcers and conditions that cause excessive stomach acid production, and to eradicate H. pylori to reduce the risk of duodenal ulcers returning. In adults and children aged 2 years and older, it also treats symptoms of gastroesophageal reflux disease (GERD) and maintains healing of acid-related damage to the lining of the food pipe. It works by blocking the acid pumps in the stomach lining, reducing stomach acid production.
What it treats
- Active duodenal ulcers in adults. - Helicobacter pylori eradication to reduce the risk of duodenal ulcers returning in adults. - Active benign gastric ulcers in adults. - Symptomatic gastroesophageal reflux disease (GERD) in patients aged 2 years and older. - Maintenance of healing of erosive esophagitis due to acid-related GERD in patients aged 2 years and older. - Conditions causing excessive stomach acid production in adults.
Safety information
Side effects
Common side effects include headache, stomach pain, nausea, diarrhea, vomiting and gas. In studies of children aged 2 to 16 years, respiratory problems and fever were the most frequently reported reactions. Serious side effects that warrant contacting a doctor include kidney inflammation (acute tubulointerstitial nephritis), diarrhea associated with Clostridium difficile infection, severe skin reactions or other allergic reactions, and new or worsening lupus. Stop taking omeprazole and seek medical assessment if kidney inflammation, a severe skin reaction, an allergic reaction or lupus develops. Other important risks include fractures of the hip, wrist or spine, particularly with long-term use; vitamin B12 deficiency with prolonged use; and low magnesium or other mineral disturbances, reported rarely with prolonged treatment. Long-term use also increases the risk of fundic gland polyps (growths in the stomach lining), especially beyond one year. Discuss these risks with your doctor.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take omeprazole if you have a known allergy to any ingredient in the capsules or to substituted benzimidazoles, the medicine family to which omeprazole belongs. Do not take it with any medicine containing rilpivirine. If omeprazole is prescribed with clarithromycin or amoxicillin, the contraindications for those antibiotics also apply. Avoid taking omeprazole with clopidogrel, St. John’s wort or rifampin. Taking it with methotrexate may increase the risk of methotrexate toxicity; your prescriber may temporarily stop omeprazole during high-dose methotrexate treatment. Omeprazole can cause kidney inflammation, severe skin reactions, and new or worsening lupus. Stop treatment and seek medical assessment if these are suspected. It may also increase the risk of Clostridium difficile-associated diarrhoea. Long-term use may increase the risk of osteoporosis-related fractures, vitamin B12 deficiency, low magnesium and stomach polyps called fundic gland polyps. Treatment should last only as long as needed for the condition being treated. In adults, improvement in symptoms does not rule out stomach cancer; further assessment may be needed. Omeprazole can also interfere with chromogranin A blood tests used to investigate neuroendocrine tumours. Tell the clinician arranging the test, as treatment needs to be paused beforehand under medical guidance.
Interactions
Do not take omeprazole with medicines containing rilpivirine. Avoid taking it with atazanavir, nelfinavir, clopidogrel, rifampin or St. John’s wort. Omeprazole can reduce the effect of some HIV medicines and clopidogrel; rifampin and St. John’s wort can reduce omeprazole levels. Discuss these medicines with your doctor: • Warfarin: blood-clotting tests need monitoring because the combination can increase the risk of serious bleeding. • Methotrexate, especially when used at high doses: omeprazole may increase and prolong methotrexate levels and toxicity. Your doctor may temporarily stop omeprazole. • Citalopram: increased levels may raise the risk of an abnormal heart rhythm. • Diazepam: increased levels may cause greater sedation. • Cilostazol, phenytoin, digoxin, tacrolimus and saquinavir: levels may increase, requiring monitoring or treatment adjustments. • Iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole and itraconazole: omeprazole’s reduction of stomach acid may reduce their absorption. Particular caution is needed with mycophenolate mofetil in transplant patients. • Cyclosporine and disulfiram: interactions have been reported, and monitoring may be needed. • Voriconazole: it can increase omeprazole levels. • Ritonavir-containing medicines: interaction advice depends on the specific product. If omeprazole is prescribed with clarithromycin and amoxicillin, your doctor should also review their interactions with your other medicines. Some clarithromycin combinations can cause serious, potentially fatal heart rhythm problems. Tell the clinician arranging tests that you take omeprazole. It can cause misleading results in chromogranin A tests for neuroendocrine tumours and secretin stimulation tests. Your doctor may temporarily stop it before testing. False-positive urine screening results for THC have also been reported; a positive result may need confirmation using another method.
Using Losec OTC
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label OMEPRAZOLE CAPSULE, DELAYED RELEASE [NUCARE PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
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