Onpattro, illustration of pre-filled syringe form (not a photo of the actual pack)

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Onpattro

Patisiran Sodium

Prescription required

$16675.00

10mg/5ml · 1 syringes

BrandBranded medicine· By Alnylam

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Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

About Onpattro

Overview

Onpattro contains patisiran, a small interfering RNA medicine. It is used to treat polyneuropathy (damage to multiple nerves) caused by hereditary transthyretin-mediated amyloidosis in adults. It works by breaking down the genetic messages used to make transthyretin, reducing this protein in the blood and its deposits in tissues.

What it treats

Polyneuropathy (damage to multiple nerves) caused by hereditary transthyretin-mediated amyloidosis in adults.

Safety information

Side effects

The most commonly reported side effects are upper respiratory tract infections and infusion-related reactions. Infusion-related reactions can be serious or life-threatening. Tell the healthcare team immediately if you develop symptoms during an infusion. The infusion may need to be slowed or interrupted, and must be stopped if a serious or life-threatening reaction occurs. Onpattro can also lower vitamin A levels in the blood. The label recommends vitamin A supplementation. Contact your doctor if you develop eye symptoms that could suggest vitamin A deficiency; referral to an eye specialist is recommended.

When to call your doctor

- Alert your healthcare team immediately if you notice symptoms of a reaction during your infusion. - Contact your doctor if you develop eye symptoms. Onpattro can lower vitamin A levels, and you may need to see an eye specialist.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Using Onpattro

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label ONPATTRO (PATISIRAN) INJECTION, LIPID COMPLEX [ALNYLAM PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).

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