Urocit‑K, illustration of tablet form (not a photo of the actual pack)

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Urocit‑K

Potassium Citrate

Prescription required

$91.00

15MEQ · 1 tablets · 1 days supply

BrandBranded medicine· By Mission Pharmacal

$2730.00 per month

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Annual cost

$33215a year at this pack size

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About Urocit‑K

Overview

Urocit-K is a prescription extended-release tablet containing potassium citrate. It is used to manage renal tubular acidosis with calcium stones and calcium oxalate kidney stones associated with low citrate levels in the urine. It is also used to manage uric acid stones, with or without calcium stones. It works by making urine less acidic and increasing urinary citrate, which makes conditions less favorable for certain stone-forming crystals.

What it treats

Renal tubular acidosis (RTA) with calcium stones. Calcium oxalate kidney stones associated with low citrate levels in the urine, regardless of cause. Uric acid stones, with or without calcium stones.

Safety information

Side effects

Urocit-K may cause abdominal discomfort, nausea, vomiting, diarrhea or loose stools due to irritation of the digestive tract. Taking it with meals or snacks may help. The tablet’s matrix may appear intact in the stool. Serious risks include high blood potassium, which can develop quickly without symptoms and may cause cardiac arrest or death. This is particularly a concern in people whose bodies cannot remove potassium properly, including those with chronic kidney failure, severe heart muscle damage or heart failure. Blood tests and ECGs are needed to monitor for this risk. Stop taking Urocit-K and seek immediate medical attention if you develop severe vomiting, abdominal pain or bleeding from the digestive tract. These may indicate serious bowel injury, including blockage or perforation.

When to call your doctor

• Stop taking Urocit-K and seek medical attention immediately if you have severe vomiting, abdominal pain or bleeding from the stomach or intestines.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not take Urocit-K if you have high blood potassium or a condition that increases this risk, including chronic kidney failure, uncontrolled diabetes, acute dehydration, adrenal insufficiency or extensive tissue breakdown. Strenuous exercise when you are not physically conditioned can also increase this risk. Do not take it with potassium-sparing medicines such as triamterene, spironolactone or amiloride. Urocit-K must not be used if you have: • Delayed or blocked tablet passage through the digestive tract, including delayed stomach emptying, compression of the oesophagus, or a narrowed or blocked intestine; this also applies if you take anticholinergic medicines. • Peptic ulcer disease. • An active urinary tract infection. • Reduced kidney function with a glomerular filtration rate below 0.7 mL/kg/min. Avoid Urocit-K if you have a condition that prevents your body from removing potassium properly, including severe heart muscle damage or heart failure. Dangerously high potassium can develop quickly without symptoms and may cause cardiac arrest. Monitoring includes periodic blood tests and ECGs. Stop taking Urocit-K immediately and seek medical assessment if you develop severe vomiting, abdominal pain or bleeding from the digestive tract. These symptoms require investigation for a bowel blockage or perforation. During pregnancy or breastfeeding, Urocit-K should be used only if clearly needed. Its effects on an unborn baby, reproductive capacity and the potassium content of breast milk are unknown. Safety and effectiveness in children have not been established.

Interactions

Urocit-K should not be taken with potassium-sparing diuretics such as triamterene, spironolactone or amiloride, because the combination can cause severely high blood potassium levels. Tell your doctor if you take ACE inhibitors, angiotensin receptor blockers (ARBs), eplerenone, aliskiren or nonsteroidal anti-inflammatory drugs (NSAIDs). These medicines can cause potassium retention, so blood potassium levels need close monitoring when they are used with Urocit-K. Medicines that slow movement through the digestive tract, such as anticholinergics, may increase stomach and intestinal irritation from Urocit-K.

Using Urocit‑K

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label UROCIT-K (POTASSIUM CITRATE) TABLET, EXTENDED RELEASE [MISSION PHARMACAL COMPANY] (DailyMed, retrieved 19 September 2026).

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