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Xenazine
Tetrabenazine
$600.00
25mg · 2 × 112 tablets · 3 months supply
BrandBranded medicine
$200.00 per month
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Annual cost
$3000a year at this pack size
Prescription required
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FDA boxed warningDepression and suicidality
XENAZINE can increase the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington's disease. Anyone considering the use of XENAZINE must balance the risks of depression and suicidality with the clinical need for control of chorea. Close observation of patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior should accompany therapy. Patients, their caregivers, and families should be informed of the risk of depression and suicidality and should be instructed to report behaviors of concern promptly to the treating physician.
Particular caution should be exercised in treating patients with a history of depression or prior suicide attempts or ideation, which are increased in frequency in Huntington's disease. XENAZINE is contraindicated in patients who are actively suicidal, and in patients with untreated or inadequately treated depression.
Increases the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington's disease
Balance risks of depression and suicidality with the clinical need for control of chorea when considering the use of XENAZINE
Monitor patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior
Inform patients, caregivers and families of the risk of depression and suicidality and instruct to report behaviors of concern promptly to the treating physician
Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation
About Xenazine
Overview
Xenazine contains tetrabenazine and is taken by mouth as a tablet. It is used to treat chorea associated with Huntington’s disease. Its exact effect on chorea is not fully understood, but it is thought to work by blocking a transporter called VMAT2, reducing stores of certain chemical messengers, including dopamine, in nerve endings.
What it treats
Chorea associated with Huntington’s disease.
Safety information
Side effects
Common side effects of Xenazine include sleepiness or sedation, fatigue, difficulty sleeping, depression, restlessness or an inability to sit still (akathisia), anxiety or worsening anxiety, and nausea. Sleepiness may impair your ability to drive or operate complex machinery. Contact a doctor promptly for new or worsening depression, agitation, restlessness, muscle stiffness or Parkinson-like symptoms, or worsening thinking or ability to carry out daily activities. Seek urgent medical help for suicidal thoughts or behaviour. Other serious side effects listed in the label include neuroleptic malignant syndrome (NMS), changes in the heart’s electrical activity called QTc prolongation, low blood pressure, including when standing up, and increased levels of the hormone prolactin. These also warrant medical attention.
FDA boxed warning
Depression and suicidality
XENAZINE can increase the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington's disease. Anyone considering the use of XENAZINE must balance the risks of depression and suicidality with the clinical need for control of chorea. Close observation of patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior should accompany therapy. Patients, their caregivers, and families should be informed of the risk of depression and suicidality and should be instructed to report behaviors of concern promptly to the treating physician.
Particular caution should be exercised in treating patients with a history of depression or prior suicide attempts or ideation, which are increased in frequency in Huntington's disease. XENAZINE is contraindicated in patients who are actively suicidal, and in patients with untreated or inadequately treated depression.
Increases the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington's disease
Balance risks of depression and suicidality with the clinical need for control of chorea when considering the use of XENAZINE
Monitor patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior
Inform patients, caregivers and families of the risk of depression and suicidality and instruct to report behaviors of concern promptly to the treating physician
Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Xenazine if you are actively suicidal, have untreated or inadequately treated depression, or have liver impairment. Do not take it with deutetrabenazine, valbenazine, monoamine oxidase inhibitors (MAOIs) or reserpine. At least 14 days must pass after stopping an MAOI, and at least 20 days after stopping reserpine, before starting Xenazine. Treatment needs regular review for worsening mood, thinking ability, muscle stiffness or ability to carry out daily activities. Restlessness, agitation, an inability to sit still or Parkinson-like symptoms may require a treatment change. Xenazine must be stopped if neuroleptic malignant syndrome occurs. Strong CYP2D6 inhibitors, such as fluoxetine and paroxetine, require prescribing precautions. Combining Xenazine with other medicines that prolong the heart’s QT interval is not recommended. Sleepiness or sedation may impair driving or operating complex machinery. During pregnancy, Xenazine may harm the unborn baby, based on animal studies.
Using Xenazine
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label XENAZINE (TETRABENAZINE) TABLET [LUNDBECK PHARMACEUTICALS LLC] (DailyMed, retrieved 19 September 2026).
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