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Depacon
Sodium Valproate
$85.00
200mg · 5 × 40 tablets · 3 months supply
Brand· By CTS
$28.33 per month
Brand or generic
Generic packs carry the same active ingredient at the same strength.
Strength
How long a supply?
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Annual cost
$306a year at this pack size
Prescription required
Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.
200mg
500mg
FDA boxed warningLife threatening adverse reactions
Hepatotoxicity
General Population:
Patients with Mitochondrial Disease:
There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase γ (POLG) gene (e.g.,Alpers Huttenlocher Syndrome). Divalproex sodium extended-release tablets are contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder
. In patients over two years of age who are clinically suspected of having a hereditary mitochondrial disease, divalproex sodium extended-release tablets should only be used after other anticonvulsants have failed. This older group of patients should be closely monitored during treatment with divalproex sodium extended-release tablets for the development of acute liver injury with regular clinical assessments and serum liver testing. POLG mutation screening should be performed in accordance with current clinical practice
Fetal Risk
Valproate can cause major congenital malformations, particularly neural tube defects (e.g., spina bifida). In addition, valproate can cause decreased IQ scores and neurodevelopmental disorders following in utero exposure.
Valproate is therefore contraindicated for prophylaxis of migraine headaches in pregnant women and in women of childbearing potential who are not using effective contraception
Valproate should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable.
Valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable. In such situations, effective contraception should be used
A Medication Guide describing the risks of valproate is available for patients
Pancreatitis
About Depacon
Overview
Depacon is a prescription medicine containing sodium valproate. It is used to treat epilepsy and help control seizures. It works by reducing excessive electrical activity in the brain.
What it treats
Epilepsy, including several types of seizures. Manic episodes associated with bipolar disorder.
Safety information
Side effects
Common side effects of sodium valproate include nausea, vomiting, diarrhoea, abdominal discomfort, tremor, sleepiness, dizziness, weight gain and hair thinning or loss. Serious side effects can include liver damage, inflammation of the pancreas, reduced blood platelets and raised ammonia levels in the blood. Contact a doctor urgently for yellowing of the skin or eyes, dark urine, unusual tiredness or loss of appetite; severe or persistent abdominal pain, especially with vomiting; unexplained bruising or bleeding; or new confusion, marked drowsiness or reduced alertness. Seek immediate medical help for a severe rash, blistering or peeling skin, swelling of the face or throat, or difficulty breathing. New or worsening depression, unusual changes in mood or behaviour, or thoughts of self-harm also require urgent medical attention.
FDA boxed warning
Life threatening adverse reactions
Hepatotoxicity
General Population:
Patients with Mitochondrial Disease:
There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase γ (POLG) gene (e.g.,Alpers Huttenlocher Syndrome). Divalproex sodium extended-release tablets are contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder
. In patients over two years of age who are clinically suspected of having a hereditary mitochondrial disease, divalproex sodium extended-release tablets should only be used after other anticonvulsants have failed. This older group of patients should be closely monitored during treatment with divalproex sodium extended-release tablets for the development of acute liver injury with regular clinical assessments and serum liver testing. POLG mutation screening should be performed in accordance with current clinical practice
Fetal Risk
Valproate can cause major congenital malformations, particularly neural tube defects (e.g., spina bifida). In addition, valproate can cause decreased IQ scores and neurodevelopmental disorders following in utero exposure.
Valproate is therefore contraindicated for prophylaxis of migraine headaches in pregnant women and in women of childbearing potential who are not using effective contraception
Valproate should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable.
Valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable. In such situations, effective contraception should be used
A Medication Guide describing the risks of valproate is available for patients
Pancreatitis
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take sodium valproate if you are allergic to it or any tablet ingredient, have active liver disease or significant liver dysfunction, a urea cycle disorder, or a known mitochondrial disorder caused by a POLG gene mutation. Sodium valproate can cause serious birth defects and developmental problems in children exposed during pregnancy. It must not be used for migraine prevention during pregnancy or by anyone who could become pregnant and is not using effective contraception. For other conditions, use during pregnancy requires specialist assessment and should be considered only when suitable alternatives are ineffective or cannot be tolerated. Anyone who could become pregnant needs specialist advice about contraception and treatment risks. Do not stop treatment suddenly if pregnancy occurs; contact the prescriber promptly. Extra caution and monitoring are needed with a history of liver or pancreatic problems, kidney impairment, bleeding disorders or low platelet counts, or suspected inherited metabolic disease. Young children, particularly those taking several seizure medicines, have a greater risk of serious liver injury. Tell the prescriber about all other medicines being taken, as important interactions can occur.
Interactions
Sodium valproate can interact with other medicines. Tell your doctor or pharmacist about all prescription medicines, over-the-counter products, vitamins and herbal supplements you take, especially: • Other epilepsy medicines, including lamotrigine, carbamazepine, phenytoin, phenobarbital and primidone. These combinations can change medicine levels or increase side effects. Valproate increases lamotrigine levels and the risk of serious skin reactions. • Topiramate, which can increase the risk of high blood ammonia and an abnormally low body temperature when combined with valproate. • Carbapenem antibiotics, such as meropenem, imipenem and ertapenem. These can greatly reduce valproate levels and lead to loss of seizure control. • Aspirin and blood-thinning medicines such as warfarin, which may increase bleeding risk or require closer monitoring. • Rifampicin, which can reduce valproate levels. • Cannabidiol, which may increase the risk of liver problems. • Sleeping tablets, sedatives and other medicines that cause drowsiness, which can increase sedation. Avoid alcohol, as it can worsen drowsiness and impair alertness. Check with your doctor or pharmacist before starting or stopping any medicine or supplement.
Using Depacon
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label DIVALPROEX SODIUM TABLET, FILM COATED, EXTENDED RELEASE [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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