Enbrel, illustration of injection pen form (not a photo of the actual pack)

Illustrative image.

Enbrel

Etanercept

Prescription required

$1500.00

25mg · 3 × 4 pre-filled syringe · 3 months supply

BrandBranded medicine· By Wyeth

$500.00 per month

Strength

How long a supply?

1 month$500.00 a month
3 months$500.00 a month
6 months$500.00 a month
Supplied from Israel

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Ships cold, in insulated packing

This medicine ships in insulated packing with coolant and carries its own shipping charge, shown at checkout.

Annual cost

$6500a year at this pack size

Prescription required

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25mg

50mg

FDA boxed warningSerious infections and malignancies

SERIOUS INFECTIONS

Enbrel should be discontinued if a patient develops a serious infection or sepsis during treatment.

Perform test for latent TB; if positive, start treatment for TB prior to starting Enbrel.

Monitor all patients for active TB during treatment, even if initial latent TB test is negative.

MALIGNANCIES

Read this with the rest of the clinical information

About Enbrel

Overview

Enbrel (etanercept) is a tumor necrosis factor (TNF) blocker. It treats rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and plaque psoriasis in adults. In children, it treats polyarticular juvenile idiopathic arthritis and juvenile psoriatic arthritis from age 2, and plaque psoriasis from age 4. It works by binding to TNF, a protein involved in inflammation, and blocking its activity.

What it treats

- Rheumatoid arthritis in adults - Psoriatic arthritis in adults - Ankylosing spondylitis in adults - Plaque psoriasis in adults and children aged 4 years and older - Polyarticular juvenile idiopathic arthritis in children aged 2 years and older - Juvenile psoriatic arthritis in children aged 2 years and older

Safety information

Side effects

The most common side effects of Enbrel are infections and reactions at the injection site, each reported in more than 5% of patients. Contact your doctor promptly if you develop an infection. Enbrel should not be started during an active infection and should be stopped if an infection becomes serious. Other serious risks include new or worsening disorders that damage the protective covering of nerves, new or worsening heart failure, reactivation of hepatitis B, lupus-like syndrome and autoimmune hepatitis. Cases of lymphoma have been observed in patients receiving TNF-blocking medicines such as Enbrel. Contact your doctor if you develop symptoms of these conditions. People previously infected with hepatitis B need monitoring during treatment and for several months afterward. Seek immediate medical attention for a severe allergic reaction, including anaphylaxis, or symptoms of serious blood disorders such as pancytopenia or aplastic anemia, which involve low blood cell counts.

FDA boxed warning

Serious infections and malignancies

SERIOUS INFECTIONS

Enbrel should be discontinued if a patient develops a serious infection or sepsis during treatment.

Perform test for latent TB; if positive, start treatment for TB prior to starting Enbrel.

Monitor all patients for active TB during treatment, even if initial latent TB test is negative.

MALIGNANCIES

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

- Seek immediate medical attention for a serious infection or severe illness while taking Enbrel. - Get immediate medical help for a severe allergic reaction. - Seek immediate medical attention for symptoms of very low blood cell counts or failure of the bone marrow to make enough blood cells.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not use Enbrel if you have sepsis. Do not start treatment while you have an active infection. If an infection develops during treatment, it needs close monitoring; Enbrel should be stopped if the infection becomes serious. Conditions requiring caution include demyelinating disease (damage to the protective covering of nerves), congestive heart failure and previous hepatitis B infection. Demyelinating disease and heart failure may develop or worsen. People previously infected with hepatitis B need monitoring for reactivation during treatment and for several months afterwards. Serious fungal infections should be considered if severe illness develops, particularly in people who live in or travel to areas where these infections are common. Lymphoma has been reported in people receiving TNF-blocking medicines such as Enbrel. Seek immediate medical attention if symptoms of pancytopenia or aplastic anaemia (serious blood cell disorders) develop. Enbrel may need to be stopped. Anaphylaxis and other serious allergic reactions may occur. Enbrel should be stopped if a lupus-like syndrome or autoimmune hepatitis develops.

Interactions

Avoid live vaccines while using Enbrel. Tell your doctor if you take anakinra, which increases the risk of serious infection, or abatacept, which increases the risk of serious side effects, including infections, when used with Enbrel. Using cyclophosphamide with Enbrel is not recommended. Specific drug interaction studies have not been conducted with Enbrel.

Using Enbrel

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use and how long it may be kept at room temperature afterwards. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label ENBREL (ETANERCEPT) KIT ENBREL (ETANERCEPT) SOLUTION [IMMUNEX CORPORATION] (DailyMed, retrieved 19 September 2026).

Patient information and references

Official and supporting information to read alongside advice from your prescriber or pharmacist.

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