Fycompa, illustration of tablet form (not a photo of the actual pack)

Illustrative image.

Fycompa

Perampanel

Prescription required

$124.00

2mg · 4 × 7 tablets · 1 month supply

BrandBranded medicine· By Eisai (distributed by Catalyst Pharmaceuticals)

$124.00 per month

Strength

How long a supply?

1 month$124.00 a month
Supplied from Israel

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Annual cost

$1612a year at this pack size

Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

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Standard

FDA boxed warningSerious psychiatric and behavioral reactions

Serious or life-threatening psychiatric and behavioral adverse reactions including aggression, hostility, irritability, anger, and homicidal ideation and threats have been reported in patients taking FYCOMPA.

These reactions occurred in patients with and without prior psychiatric history, prior aggressive behavior, or concomitant use of medications associated with hostility and aggression.

Advise patients and caregivers to contact a healthcare provider immediately if any of these reactions or changes in mood, behavior, or personality that are not typical for the patient are observed while taking FYCOMPA or after discontinuing FYCOMPA.

Closely monitor patients particularly during the titration period and at higher doses.

FYCOMPA should be reduced if these symptoms occur and should be discontinued immediately if symptoms are severe or are worsening.

Monitor patients for these reactions as well as for changes in mood, behavior, or personality that are not typical for the patient, particularly during the titration period and at higher doses

Read this with the rest of the clinical information

About Fycompa

Overview

Fycompa tablets contain perampanel, a medicine for epilepsy. It treats partial-onset seizures, including those that spread to involve both sides of the brain, in people aged 4 years and older. It is also used alongside other epilepsy medicines to treat primary generalized tonic-clonic seizures in people aged 12 years and older. It works by blocking AMPA receptors, which receive signals from the chemical messenger glutamate.

What it treats

- Partial-onset seizures, with or without seizures that become generalized, in people with epilepsy aged 4 years and older. - Primary generalized tonic-clonic seizures in people with epilepsy aged 12 years and older, used alongside other seizure medicines.

Safety information

Side effects

Common side effects include dizziness, sleepiness, tiredness, irritability, falls, nausea, weight gain, a spinning sensation (vertigo), problems with coordination, headache, vomiting, bruising, abdominal pain and anxiety. Use caution when driving or operating machinery. Contact a doctor promptly for serious changes in mood or behaviour, suicidal thoughts or behaviour, problems with walking, or falls and injuries. Seek urgent medical help for a serious allergic reaction called DRESS (drug reaction with eosinophilia and systemic symptoms), which can affect multiple organs. Stopping Fycompa may increase seizure frequency in people with epilepsy. Discuss stopping treatment with your prescriber.

FDA boxed warning

Serious psychiatric and behavioral reactions

Serious or life-threatening psychiatric and behavioral adverse reactions including aggression, hostility, irritability, anger, and homicidal ideation and threats have been reported in patients taking FYCOMPA.

These reactions occurred in patients with and without prior psychiatric history, prior aggressive behavior, or concomitant use of medications associated with hostility and aggression.

Advise patients and caregivers to contact a healthcare provider immediately if any of these reactions or changes in mood, behavior, or personality that are not typical for the patient are observed while taking FYCOMPA or after discontinuing FYCOMPA.

Closely monitor patients particularly during the titration period and at higher doses.

FYCOMPA should be reduced if these symptoms occur and should be discontinued immediately if symptoms are severe or are worsening.

Monitor patients for these reactions as well as for changes in mood, behavior, or personality that are not typical for the patient, particularly during the titration period and at higher doses

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

• Contact a healthcare provider immediately for aggression, hostility, unusual irritability or anger, or other unexpected changes in mood, behavior or personality, even after stopping Fycompa. • Seek immediate medical attention for suicidal thoughts or behavior, or thoughts or threats of killing someone else.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

The supplied FDA label lists no contraindications for Fycompa. Caution is needed because suicidal thoughts or behavior, dizziness, difficulty walking, sleepiness, fatigue, falls and injuries may occur. Use caution when driving or operating machinery. A serious drug reaction called DRESS, which can affect multiple organs, requires stopping Fycompa if no other cause is identified. Stopping treatment in people with epilepsy may increase seizure frequency. Fycompa may harm an unborn baby, based on animal studies.

Interactions

Fycompa may reduce the effectiveness of hormonal contraceptives containing levonorgestrel. Tell your doctor if you use one. Medicines such as carbamazepine, oxcarbazepine and phenytoin can lower perampanel levels in the blood. Your doctor should monitor you closely when these medicines are started or stopped and may need to adjust your Fycompa treatment.

Using Fycompa

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label FYCOMPA (PERAMPANEL) TABLET FYCOMPA (PERAMPANEL) SUSPENSION [CATALYST PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).

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