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Lovenox
Enoxaparin
$19.00
20mg · 2 vial · 2 days supply
BrandBranded medicine· By Sanofi-Aventis
$285.00 per month
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FDA boxed warningSpinal/epidural hematomas
Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH) or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:
Use of indwelling epidural catheters
Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, and other anticoagulants
A history of traumatic or repeated epidural or spinal punctures
A history of spinal deformity or spinal surgery
Optimal timing between the administration of Lovenox and neuraxial procedures is not known
Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary.
Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis
About Lovenox
Overview
Lovenox contains enoxaparin sodium, a low molecular weight heparin used to help prevent and treat blood clots. It helps prevent deep vein thrombosis (DVT) in patients having abdominal, hip replacement or knee replacement surgery, or whose movement is severely limited during an acute illness, and treats DVT with or without pulmonary embolism. It is also used to help prevent complications of unstable angina and certain heart attacks, and to treat acute ST-segment elevation heart attack (STEMI). It works by reducing the blood’s ability to form clots.
What it treats
- Prevention of deep vein thrombosis (DVT) in patients undergoing abdominal, hip replacement or knee replacement surgery, or with severely restricted mobility during acute illness. - Hospital treatment of acute DVT, with or without pulmonary embolism. - Outpatient treatment of acute DVT without pulmonary embolism. - Prevention of complications caused by reduced blood flow in unstable angina and non–Q-wave heart attack. - Treatment of acute ST-segment elevation heart attack (STEMI), managed medically or with subsequent percutaneous coronary intervention (PCI).
Safety information
Side effects
Common side effects include bleeding, anemia (low red blood cell count), a low platelet count, increased liver enzyme levels in blood tests, diarrhea, nausea, bruising, fever, swelling, shortness of breath, confusion and pain at the injection site. Contact a doctor promptly for signs of bleeding. Serious risks include severe bleeding, blood collections around the spinal cord or in the epidural space, and heparin-induced thrombocytopenia, an immune reaction that lowers platelet counts and may occur with or without blood clots. Platelet counts need close monitoring. Pregnant women with mechanical artificial heart valves and their fetuses may be at increased risk of blood clots and require more frequent monitoring.
FDA boxed warning
Spinal/epidural hematomas
Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH) or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:
Use of indwelling epidural catheters
Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, and other anticoagulants
A history of traumatic or repeated epidural or spinal punctures
A history of spinal deformity or spinal surgery
Optimal timing between the administration of Lovenox and neuraxial procedures is not known
Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary.
Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not use Lovenox if you have active major bleeding; have had immune-mediated heparin-induced thrombocytopenia (HIT, a fall in platelets) within the past 100 days or still have circulating HIT antibodies; or are allergic to enoxaparin sodium, heparin or pork products. The multiple-dose vial must not be used by anyone allergic to benzyl alcohol. Lovenox can cause bleeding and HIT, with or without blood clots. Monitoring for bleeding and close monitoring of platelet counts are needed. Older adults and people with low body weight need particular attention for signs of bleeding. Severe kidney impairment requires the prescriber to adjust treatment. Pregnant women with mechanical prosthetic heart valves and their fetuses may be at increased risk of blood clots; more frequent monitoring and prescriber review of treatment are needed. Lovenox must not be used interchangeably with heparin or other low-molecular-weight heparins.
Interactions
Medicines that increase bleeding risk may interact with Lovenox. These include other anticoagulants (blood thinners), platelet inhibitors such as aspirin, other salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, and medicines such as dipyridamole or sulfinpyrazone. Tell your doctor if you take any of these medicines. Your doctor may need to stop them before you start Lovenox. If they must be used together, close clinical monitoring and laboratory tests are needed.
Using Lovenox
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label LOVENOX (ENOXAPARIN SODIUM) INJECTION [SANOFI-AVENTIS U.S. LLC] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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