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Zepbound
Tirzepatide
$2400.00
2.5mg · 4 × 1 pre-filled pen · 1 month supply
BrandBranded medicine· By Eli lilly
$2400.00 per month
Strength
How long a supply?
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Annual cost
$31200a year at this pack size
Prescription required
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2.5mg
5mg
7.5mg
10mg
12.5mg
15mg
FDA boxed warningRisk of thyroid c-cell tumors
In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether ZEPBOUND causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined
ZEPBOUND is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
. Counsel patients regarding the potential risk for MTC with the use of ZEPBOUND and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with ZEPBOUND
In rats, tirzepatide causes thyroid C-cell tumors. It is unknown whether ZEPBOUND causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined.
About Zepbound
Overview
Zepbound contains tirzepatide and is given as an injection under the skin using a pre-filled pen. It is used with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight loss long term in adults with obesity, or adults with overweight and at least one weight-related health condition. It is also used with these lifestyle measures to treat moderate to severe obstructive sleep apnea in adults with obesity. It works by activating GIP and GLP-1 receptors, which are involved in regulating appetite and food intake.
What it treats
- Excess body weight in adults with obesity, or adults with overweight and at least one weight-related health condition, including long-term maintenance of weight loss. - Moderate to severe obstructive sleep apnea (OSA) in adults with obesity. For both uses, Zepbound is used alongside a reduced-calorie diet and increased physical activity.
Safety information
Side effects
Common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection-site reactions, tiredness, allergic reactions, burping, hair loss and acid reflux. Serious risks include: • Severe stomach or bowel side effects. • Sudden kidney injury due to dehydration. • Gallbladder disease, including gallbladder inflammation. • Inflammation of the pancreas (acute pancreatitis). • Serious allergic reactions, including anaphylaxis and angioedema (swelling beneath the skin). • Low blood sugar, which may be severe. The risk is higher when Zepbound is used with insulin or medicines that increase insulin release. • Worsening of diabetes-related damage to the retina in people with type 2 diabetes. • A risk of thyroid C-cell tumors. Contact a doctor promptly if you develop severe stomach or bowel side effects or suspect a serious reaction. Stop Zepbound and seek prompt medical attention if a serious allergic reaction is suspected. Zepbound should also be stopped if pancreatitis is suspected. People with a history of diabetes-related retinal damage should be monitored for worsening. Stomach contents entering the lungs during general anesthesia or deep sedation have been reported with this class of medicine. Tell your healthcare team about Zepbound before any planned surgery or procedure.
FDA boxed warning
Risk of thyroid c-cell tumors
In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether ZEPBOUND causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined
ZEPBOUND is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
. Counsel patients regarding the potential risk for MTC with the use of ZEPBOUND and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with ZEPBOUND
In rats, tirzepatide causes thyroid C-cell tumors. It is unknown whether ZEPBOUND causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not use Zepbound if you or anyone in your family has had medullary thyroid carcinoma, if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you have had a serious allergic reaction to tirzepatide or any other ingredient in Zepbound. Zepbound is not recommended for people with severe gastroparesis (severely delayed stomach emptying). It can cause severe digestive side effects. Side effects that cause fluid loss may lead to acute kidney injury and require kidney function monitoring. Gallbladder disease and acute pancreatitis have also been reported. Stop using Zepbound if pancreatitis is suspected. If a serious allergic reaction is suspected, stop using it and seek medical attention promptly. Low blood sugar can occur, with a higher risk, including severe episodes, when Zepbound is used with insulin or medicines that stimulate insulin release. Your prescriber may need to adjust those medicines. If you have type 2 diabetes and a history of diabetic retinopathy, your eyes should be monitored for worsening disease. Tell your healthcare team about any planned surgery or procedure. Inhalation of stomach contents into the lungs has been reported in people receiving GLP-1 medicines during general anaesthesia or deep sedation. Zepbound may harm an unborn baby. Stop using it if you become pregnant. If you use oral contraception, switch to a non-oral method or add a barrier method for 4 weeks after starting Zepbound and for 4 weeks after each dose increase.
Interactions
Zepbound slows stomach emptying, which may affect how other medicines taken by mouth are absorbed. Tell your doctor about any oral medicines you take.
Using Zepbound
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use and how long it may be kept at room temperature afterwards. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label ZEPBOUND (TIRZEPATIDE) INJECTION, SOLUTION ZEPBOUND (TIRZEPATIDE) INJECTION, SOLUTION ZEPBOUND KWIKPEN (TIRZEPATIDE) INJECTION, SOLUTION [ELI LILLY AND COMPANY] (DailyMed, retrieved 19 September 2026).
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