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Lamictal

Name: Lamictal
Brand: GSK
Availability: InStock

Lamotrigine

Prescription required

$108.00

5mg · 6 × 30 tablets · 3 months supply

Brand· By GSK

$36.00 per month

Brand or generic

Generic packs carry the same active ingredient at the same strength.

Strength

How long a supply?

1 month$36.00 a monthOne-off$36.00

3 months$36.00 a monthOne-off$108.00

6 months$36.00 a monthOne-off$216.00

Supplied from Israel

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Annual cost

$432a year at this pack size

Prescription required

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FDA boxed warningSerious skin rashes

LAMICTAL XR can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.8% (8 per 1,000) in pediatric patients (aged 2 to 16 years) receiving immediate-release lamotrigine as adjunctive therapy for epilepsy and 0.3% (3 per 1,000) in adults on adjunctive therapy for epilepsy. In a prospectively followed cohort of 1,983 pediatric patients (aged 2 to 16 years) with epilepsy taking adjunctive immediate release lamotrigine, there was 1 rash-related death. LAMICTAL XR is not approved for patients younger than 13 years. In worldwide postmarketing experience, rare cases of toxic epidermal necrolysis and/or rash-related death have been reported in adult and pediatric patients, but their numbers are too few to permit a precise estimate of the rate.

The risk of serious rash caused by treatment with LAMICTAL XR is not expected to differ from that with immediate-release lamotrigine. However, the relatively limited treatment experience with LAMICTAL XR makes it difficult to characterize the frequency and risk of serious rashes caused by treatment with LAMICTAL XR.

In addition to age, factors that may increase the risk of occurrence or the severity of rash caused by LAMICTAL XR include coadministration of LAMICTAL XR with valproate (includes valproic acid and divalproex sodium), exceeding the recommended initial dose of LAMICTAL XR, exceeding the recommended dose escalation for LAMICTAL XR., or the presence of the HLA-B*1502 allele. However, cases have occurred in the absence of these factors.

Nearly all cases of life-threatening rashes caused by immediate-release lamotrigine have occurred within 2 to 8 weeks of treatment initiation. However, isolated cases have occurred after prolonged treatment (e.g., 6 months). Accordingly, duration of therapy cannot be relied upon as means to predict the potential risk heralded by the first appearance of a rash.

Although benign rashes are also caused by LAMICTAL XR, it is not possible to predict reliably which rashes will prove to be serious or life threatening. Accordingly, LAMICTAL XR should ordinarily be discontinued at the first sign of rash, unless the rash is clearly not drug related. Discontinuation of treatment may not prevent a rash from becoming life threatening or permanently disabling or disfiguring.

Cases of life-threatening serious rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, and/or rash-related death have been caused by lamotrigine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include:

coadministration with valproate.

exceeding recommended initial dose of LAMICTAL XR.

exceeding recommended dose escalation for LAMICTAL XR.

presence of the HLA-B*1502 allele.

Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. LAMICTAL XR should be discontinued at the first sign of rash, unless the rash is clearly not drug related.

Read this with the rest of the clinical information

About Lamictal

Overview

Lamictal contains lamotrigine, an anti-seizure medicine. The supplied LAMICTAL XR label describes use alongside other seizure medicines for primary generalized tonic-clonic seizures and partial-onset seizures in people aged 13 years and older. It also covers switching people in this age group with partial-onset seizures from a single seizure medicine to lamotrigine alone. Exactly how lamotrigine works is unknown, but laboratory studies suggest it affects sodium channels in nerve cells, helping regulate the release of chemical signals that excite them.

What it treats

- Primary generalized tonic-clonic seizures in patients aged 13 years and older, used alongside other seizure medicines. - Partial-onset seizures, with or without secondary generalization, in patients aged 13 years and older, used alongside other seizure medicines or when switching from a single seizure medicine to lamotrigine alone.

Safety information

Side effects

Common side effects include dizziness, shaking (tremor), vomiting and double vision. Serious skin rashes can be life-threatening or fatal. Stop taking the medicine at the first sign of a rash unless it is clearly unrelated to the medicine, and contact a doctor immediately. Rash, fever or swollen lymph nodes may also be early signs of a severe allergic reaction called DRESS, which can damage the liver, blood or other organs and may be fatal. Other serious reactions that need immediate medical attention include: • A severe immune reaction called hemophagocytic lymphohistiocytosis (HLH), which causes inflammation throughout the body. • Serious heart rhythm problems, potentially fatal in people with certain underlying heart conditions. • Blood disorders, which may cause anemia, unexpected infections or bleeding. • Suicidal thoughts or behavior. • Aseptic meningitis, an inflammation of the membranes surrounding the brain and spinal cord. • Seizures following withdrawal of treatment, and prolonged seizures known as status epilepticus.

FDA boxed warning

Serious skin rashes

coadministration with valproate.

exceeding recommended initial dose of LAMICTAL XR.

exceeding recommended dose escalation for LAMICTAL XR.

presence of the HLA-B*1502 allele.

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

• Seek medical attention immediately for any new rash, even if it seems mild. • Get urgent medical help for fever or swollen glands, with or without a rash. • Contact a doctor immediately for unexpected bleeding or signs of infection. • Seek immediate help for thoughts of suicide or suicidal behavior.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not take Lamictal if you have had an allergic reaction to lamotrigine or any of its ingredients. This includes rash, swelling, hives, severe itching or sores on mucous membranes. Tell your prescriber if you have heart disease, heart rhythm problems, liver impairment or significant kidney impairment. Lamotrigine may cause serious, potentially fatal heart rhythm problems in people with certain underlying heart conditions. Use during pregnancy requires caution because animal studies suggest possible harm to the unborn baby. Lamotrigine can cause life-threatening skin reactions. Stop taking it at the first sign of a rash unless the rash is clearly unrelated to the medicine, and seek medical advice immediately. Rash, fever or swollen lymph nodes may signal a serious allergic reaction affecting several organs. A potentially life-threatening immune reaction called hemophagocytic lymphohistiocytosis can also occur and requires immediate assessment. Other serious risks include blood disorders, suicidal thoughts or behaviour, and meningitis not caused by infection. Seek prompt medical attention for signs of anaemia, unexpected infection or bleeding, and immediate help for suicidal thoughts or behaviour.

Interactions

Valproate can more than double lamotrigine levels. Carbamazepine, phenytoin, phenobarbital, primidone, rifampin, lopinavir/ritonavir and atazanavir/ritonavir can lower lamotrigine levels. Tell your doctor if you take any of these medicines. Estrogen-containing contraceptive pills can lower lamotrigine levels. Lamotrigine can also lower levels of levonorgestrel, a hormone in some contraceptive pills. Discuss starting or stopping estrogen-containing contraception with your doctor. Lamotrigine may increase levels of certain medicines by reducing their removal through the kidneys. Taking it with dofetilide, or similar medicines that use the OCT2 kidney transport pathway and require tightly controlled blood levels, is not recommended.

Using Lamictal

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label LAMICTAL XR (LAMOTRIGINE) TABLET, FILM COATED, EXTENDED RELEASE LAMICTAL XR (LAMOTRIGINE) KIT [GLAXOSMITHKLINE LLC] (DailyMed, retrieved 19 September 2026).

Patient information and references

Official and supporting information to read alongside advice from your prescriber or pharmacist.

Patient information leaflet (PDF)

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