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Lamictal CD
Lamotrigine
$60.00
5mg · 6 × 30 tablets · 3 months supply
BrandBranded medicine· By GlaxoSmithKline
$20.00 per month
How long a supply?
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Annual cost
$240a year at this pack size
Prescription required
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FDA boxed warningSerious skin rashes
Cases of life-threatening serious rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, and/or rash-related death have been caused by lamotrigine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include:
coadministration with valproate.
exceeding recommended initial dose of lamotrigine.
exceeding recommended dose escalation for lamotrigine.
presence of the HLA-B*1502 allele.
Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. Lamotrigine should be discontinued at the first sign of rash, unless the rash is clearly not drug related.
About Lamictal CD
Overview
Lamictal CD contains lamotrigine, an antiepileptic medicine. It is used alongside other medicines for certain seizures in people aged 2 years and older, and as a replacement for certain single epilepsy medicines in people aged 16 years and older with partial-onset seizures. It is also used for maintenance treatment of bipolar I disorder to delay further mood episodes after standard treatment, not to treat acute manic or mixed episodes. Its exact action is unknown, but it may affect sodium channels involved in nerve signalling; how it works in bipolar disorder has not been established.
What it treats
• Add-on treatment for partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures associated with Lennox-Gastaut syndrome in patients aged 2 years and older. • Partial-onset seizures in patients aged 16 years and older switching to lamotrigine alone from treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as their only seizure medicine. • Maintenance treatment of bipolar I disorder to delay further mood episodes after an acute episode has been treated with standard therapy. It is not recommended for acute manic or mixed episodes; effectiveness for treating acute mood episodes has not been established.
Safety information
Side effects
Common side effects reported in adults with epilepsy include dizziness, headache, double or blurred vision, problems with coordination, nausea, sleepiness, runny nose, sore throat and rash. Additional common effects reported in children include vomiting, infection, fever, accidental injury, diarrhoea, abdominal pain and shaking. In adults with bipolar disorder, common effects include nausea, trouble sleeping, sleepiness, back pain, tiredness, rash, runny nose, abdominal pain and dry mouth. Lamotrigine can cause life-threatening skin reactions, including Stevens–Johnson syndrome and toxic epidermal necrolysis. Stop taking it at the first sign of a rash and contact a doctor immediately, unless a doctor has clearly established that the rash is unrelated to the medicine. Serious rash is more frequent in children, and taking valproate increases the risk. Seek immediate medical assessment for fever, swollen glands or rash. These may signal a severe allergic reaction affecting several organs, or a life-threatening immune reaction called haemophagocytic lymphohistiocytosis (HLH). Severe reactions can occur without a rash and may cause organ failure. Other serious effects include blood cell disorders, liver failure, aseptic meningitis and potentially fatal abnormal heart rhythms in people with certain underlying heart conditions. Contact a doctor promptly for signs of anaemia, unexpected infection or bleeding. Report new or worsening depression, unusual mood or behaviour changes, or suicidal thoughts or behaviour immediately.
FDA boxed warning
Serious skin rashes
Cases of life-threatening serious rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, and/or rash-related death have been caused by lamotrigine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include:
coadministration with valproate.
exceeding recommended initial dose of lamotrigine.
exceeding recommended dose escalation for lamotrigine.
presence of the HLA-B*1502 allele.
Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. Lamotrigine should be discontinued at the first sign of rash, unless the rash is clearly not drug related.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take lamotrigine if you are allergic to lamotrigine or any of the tablet’s ingredients. Tell your prescriber if you have heart disease, a heart rhythm disorder, liver or kidney impairment, a history of allergy or rash with other antiepileptic medicines, or are pregnant. Animal studies suggest a risk of harm to the unborn baby. Liver or kidney impairment may require treatment adjustments. Lamotrigine can cause serious, sometimes fatal skin reactions. Risk is increased with valproate and when prescribed starting or dose-increase instructions are exceeded. Certain people of Asian ancestry who carry the HLA-B*1502 genetic variant have an increased risk of severe skin reactions, but these reactions can occur in anyone. Stop taking lamotrigine at the first sign of rash unless a healthcare professional determines that it is clearly unrelated to the medicine, and seek medical advice immediately. Fever or swollen glands, with or without a rash, may signal a life-threatening immune or allergic reaction affecting several organs and require immediate medical assessment. Lamotrigine may also cause blood disorders and aseptic meningitis. Report unexpected infections, bleeding or signs of anaemia to your healthcare provider. In people with certain underlying heart conditions, lamotrigine may cause serious or fatal rhythm disturbances. Other sodium channel-blocking medicines may increase this risk. Monitor for new or worsening depression, suicidal thoughts or unusual changes in mood or behaviour, and report these promptly.
Interactions
Tell your doctor if you take valproate, which increases lamotrigine levels, or carbamazepine, phenytoin, phenobarbital, primidone or rifampin, which lower them. Estrogen-containing oral contraceptives and the protease inhibitor combinations lopinavir/ritonavir and atazanavir/lopinavir also lower lamotrigine levels. Taking lamotrigine with certain medicines handled by a transporter called OCT2 is not recommended when those medicines have only a small margin between effective and harmful levels. Ask your doctor whether any of your medicines fall into this group.
Using Lamictal CD
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label LAMOTRIGINE TABLET [PD-RX PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
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