ProQuad, illustration of injection vial form (not a photo of the actual pack)

Illustrative image.

ProQuad

Measles, Mumps, Rubella And Varicella Virus Vaccine Live

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$175.00

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BrandBranded medicine· By Merck

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About ProQuad

Overview

ProQuad is a combined vaccine containing weakened live measles, mumps, rubella and varicella viruses. It is used to help prevent these four diseases in children aged 12 months through 12 years. It works by stimulating the immune system to develop immunity against these viruses.

What it treats

ProQuad is used to help prevent measles, mumps, rubella and varicella (chickenpox) in children aged 12 months through 12 years.

Safety information

Side effects

Common side effects include pain, tenderness, soreness, redness or swelling at the injection site, fever and irritability. A measles-like rash has also been reported. Fever-related seizures are a serious risk. In children aged 12–23 months who have not previously been vaccinated against these infections or had them, the first ProQuad vaccination is associated with higher rates of fever and fever-related seizures 5–12 days afterwards than when the component vaccines are given separately. Seek urgent medical help if a seizure occurs. Tell the doctor before vaccination if your child or a family member has a history of fever-related seizures.

When to call your doctor

• Seek medical attention immediately if your child has a seizure with fever after vaccination, particularly 5 to 12 days afterward.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

ProQuad must not be given to anyone who is allergic to any vaccine component, has a suppressed immune system, has a moderate or severe illness with fever, has active untreated tuberculosis, or is pregnant. Pregnancy should be avoided for 3 months after vaccination. Extra caution is needed in children with a personal or family history of fever-related seizures, a history of anaphylaxis or an immediate allergic reaction after eating eggs, or a low platelet count (thrombocytopenia). Immune function should be assessed before vaccination if there is a family history of an inherited immune deficiency. In previously unvaccinated children aged 12 to 23 months with no history of measles, mumps, rubella or varicella infection, the first ProQuad vaccination is associated with more fever and fever-related seizures 5 to 12 days afterwards than M-M-R II and VARIVAX given separately. Immune globulins and other blood products should not be given at the same time as ProQuad. Avoid salicylates for 6 weeks after vaccination. Avoid close contact with people at high risk who are susceptible to varicella (chickenpox), because the vaccine’s varicella virus may be transmitted to them.

Interactions

Tell your doctor if you are receiving immune globulins or other blood products, as these may interfere with the expected immune response to ProQuad when given at the same time. ProQuad may temporarily reduce the skin’s response to a PPD tuberculin skin test. Let your doctor know if you are due to have this test. ProQuad may be given at the same visit as Haemophilus influenzae type b (Hib) conjugate, hepatitis B, pneumococcal 7-valent conjugate or inactivated hepatitis A vaccines, using separate injection sites.

Using ProQuad

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label PROQUAD (MEASLES, MUMPS, RUBELLA AND VARICELLA VIRUS VACCINE LIVE) INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION [MERCK SHARP & DOHME LLC] (DailyMed, retrieved 19 September 2026).

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